GYN

Cancer Control

  • NRG CC004– A Randomized Phase II Double Blind Dose Finding Trial of Bupropion Versus Placebo for Sexual Desire in Women with Breast or Gynecologic Cancer

UTERINE

  • GOG 0238 – A Randomized Trial of Pelvic Irradiation With or Without Concurrent Weekly Cisplatin in Patients with Pelvic Only Recurrence of Carcinoma of the Uterine Corpus
  • NRG-GY006– A Randomized Phase II Trial of Radiation Therapy and Cisplatin Alone or in Combination with Intravenous Triapine in Women with Newly Diagnosed Bulky Stage IB2, Stage II, IIIB, IVA Cancer of the Uterine Cervix or Stage II-IVA Vaginal Cancer (Temporarily Closed to Accrual)

ENDOMETRIAL

  • GOG 0286B– A Randomized Phase II/III Study of Paclitaxel/Carboplatin/Metformin Versus Paclitaxel/Carboplatin/Placebo as Initial Therapy forMeasurable Stage III or IVA, Stage IVB, or Recurrent Endometrial Cancer
  • NRG GY008– A Phase II Evaluation of Copanlisib, A Selective Inhibitor of P13KCA in Patients with Persistent or Recurrent Endometrial Carcinoma Harboring PIK3CA Hotspot Mutations (Temporarily Closed)

CERVIX

  • GOG 0263 – Randomized Phase III Clinical Trial of Adjuvant Radiation versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated with Initial Radical Hysterectomy and Pelvic Lymphadenectomy
  • RTOG 0724– A Randomized Phase III Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma Following Radical Hysterectomy
  • NRG-GY006– A Randomized Phase II Trial of Radiation Therapy and Cisplatin Alone or in Combination with Intravenous Triapine in Women with Newly Diagnosed Bulky Stage IB2, Stage II, IIIB, IVA Cancer of the Uterine Cervix or Stage II-IVA Vaginal Cancer (Temporarily Closed to Accrual)
  • GOG 0278– Evaluation of Physical Function and Quality of Life (QOL) Before and After Non-radical Surgical Therapy in Early Stage Cervical Cancer
  • GOG 0237– Comparative analysis of CA-IX, p16, Proliferative Markers, and Human Papilloma Virus in the Diagnosis of Significant Cervical Lesions in Patients with a Cytologic Diagnosis of Atypical Glandular Cells (AGC)

OVARIAN/FALLOPIAN TUBE

  • GOG 0264– A Randomized Phase II  Study of Paclitaxel and Carboplatin vs. Bleomycin, Etoposide, and Cisplatin for Newly Diagnosed Advanced Stage and Recurrent Chemonaive Sex-Cord Stromal Tumors or the Ovary
  • GOG 0225– Can Diet and Exercise Modulate Ovarian, Fallopian Tube and Primary Peritoneal Cancer Progression-Free Survival
  • NRG-GY004- A Phase III study comparing single-agent Olaparib or the Combination of Cediranib and Olaparib to Standard Platinum-based Chemotherapy in women with Recurrent Platinum-sensitive Ovarian, Fallopian tube, or Primary Peritoneal Cancer
  • NRG-GY005– A Randomized Phase II/III study of the Combination of Cediranib and Olaparib compared to Cediranib or Olaparib alone, or Standard of care chemotherapy in women with Recurrent Platinum-Resistant or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (Temporarily closed to accrual)

Metastatic

  • RTOG 0631– A Randomized Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis